• Pain management · Sep 2020

    Review

    Naldemedine for the treatment of opioid-induced constipation in adults with chronic noncancer pain.

    • Joy J Liu, Sarah E Quinton, and Darren M Brenner.
    • Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
    • Pain Manag. 2020 Sep 1; 10 (5): 301-306.

    AbstractThis review aims to summarize the efficacy data for naldemedine, a member of the novel peripherally acting μ-opioid receptor antagonists (PAMORAs), which gained US FDA approval for the treatment of opioid-induced constipation in adults with chronic noncancer pain-related syndromes in 2017. In Phase III trials, patients receiving naldemedine were significantly more likely to meet the primary end point ≥3 spontaneous bowel movements/week and an increase of ≥1 spontaneous bowel movement/week from baseline for at least 9/12 weeks compared to placebo (p < 0.0001). The most frequent adverse events were abdominal pain (8%) and diarrhea (7%). Based on available data, naldemedine appears to be an effective and safe first-line therapy for the treatment of opioid-induced constipation in adults with chronic noncancer pain.

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