• Pediatric emergency care · Dec 1989

    Case Reports

    Treatment of severe imipramine poisoning complicated by a negative history of drug ingestion.

    • J Tribble, E Weinhouse, J Garland, and K Wendelberger.
    • Medical College of Wisconsin, Department of Pediatrics, Milwaukee.
    • Pediatr Emerg Care. 1989 Dec 1; 5 (4): 234-7.

    AbstractThe wide use of imipramine (Tofranil) for the treatment of nocturnal enuresis continues in spite of the unique dangers associated with this drug. Young children are particularly susceptible to the potentially lethal central nervous system and cardiovascular toxicities, yet the toxic potential of imipramine remains unrecognized by both parents and too many physicians. Management of severe imipramine intoxication can be difficult. This report describes a 12-month-old patient with severe imipramine intoxication whose treatment was complicated by a negative history at presentation.

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