Patient adherence, compliance, and perspectives on evolocumab

Patient Prefer Adher · Jan 2018

Review

Patient adherence, compliance, and perspectives on evolocumab for the management of resistant hypercholesterolemia.

Evolocumab is a PCSK9 inhibitor which is administered subcutaneously, and when added to statin therapy it has been shown to cause a significant incremental LDL-C reduction, leading to a reduction of cardiovascular risk. Evolocumab has a favorable side effect profile, and its self-administration at home appears to be safe and effective with the appropriate training and instructions from a health care provider. ⋯ However, further larger studies are needed for a more definitive assessment of the short- and long-term patient adherence rates to evolocumab. In addition, reductions in the price of evolocumab may also be necessary to improve cost-effectiveness of the drug.

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- Constantine E Kosmas, Delia Silverio, Julio Ovalle, Peter D Montan, and Eliscer Guzman.
- Division of Cardiology, Department of Medicine, Mount Sinai Hospital, New York, NY, USA, cekosmas1@gmail.com.
- Patient Prefer Adher. 2018 Jan 1; 12: 2263-2266.
AbstractEvolocumab is a PCSK9 inhibitor which is administered subcutaneously, and when added to statin therapy it has been shown to cause a significant incremental LDL-C reduction, leading to a reduction of cardiovascular risk. Evolocumab has a favorable side effect profile, and its self-administration at home appears to be safe and effective with the appropriate training and instructions from a health care provider. Current studies are showing encouraging results regarding adherence to evolocumab in real-life settings, and adherence rates to evolocumab appear to be better than those to statins. However, further larger studies are needed for a more definitive assessment of the short- and long-term patient adherence rates to evolocumab. In addition, reductions in the price of evolocumab may also be necessary to improve cost-effectiveness of the drug.

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Patient adherence, compliance, and perspectives on evolocumab for the management of resistant hypercholesterolemia.

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