• Farzaneh Habibi, Mohammad Emadoddin Habibi, Ali Gharavinia, MahdaviSadegh BaradaranSBGastrointestinal Diseases Research Center, Poursina Hakim Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran, Mohammad Javad Akbarpour, Abdolmehdi Baghaei, and Mohammad Hassan Emami.
• Gastrointestinal Diseases Research Center, Poursina Hakim Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
• J Res Med Sci. 2017 Jan 1; 22: 104.

BackgroundInflammatory bowel disease (IBD) has a significant impact on health-related quality of life (HRQOL). This study aims to investigate the variables which can be attributed to HRQOL in IBD patients.Materials And MethodsSeventy-one patients filled in IBD questionnaire (IBDQ-32), Pittsburgh sleep quality index questionnaire, and sociodemographic questionnaire. Disease activity was assessed by Crohn's disease activity index (CDAI) and ulcerative colitis activity index (UCAI). The correlations of sleep quality, sociodemographic variables, and disease characteristics with IBDQ were investigated.ResultsIBDQ-32 mean score was lower in patients who had hospitalization (P = 0.01), poor sleep quality (P < 0.001), anemia (P = 0.03), more severe disease (P = 0.01), and those who had not consumed folic acid (P = 0.01) relative to their counterparts. A multivariate regression analysis identified the predictors of decreased HRQOL as not consuming folic acid (P = 0.008), poor sleep quality (P = 0.014), and disease severity (P = 0.043).ConclusionImpaired HRQOL was significantly associated with poor sleep quality, lack of folic acid consumption, and disease severity in IBD patients. Therefore, evaluation of folic acid level and efficacy of its supplementation in prospective studies is recommended. Treatment of sleep disturbance with pharmacological agents and nonpharmacological methods should be kept in mind as well.

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