• Kiana Shirani, Elahe Seydayi, and Kiarash Salimi Boroujeni.
• Isfahan Infectious Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
• J Res Med Sci. 2019 Jan 1; 24: 103.

BackgroundExtended-spectrum ß-lactamase (ESBL)-producing Enterobacteriaceae seem to have an extended antibiotic resistance, but have different resistance patterns throughout different sites and regions. This study aimed to evaluate the antibiotic resistance pattern of ESBL-producing Escherichia coli.Materials And MethodsOne hundred swab samples from patients hospitalized due to a clinical suspicion of any kind of infection (with manifestations such as fever, leukocytosis, and an active urinalysis result) were processed in Alzahra Microbiology Laboratory, Isfahan, Iran. Isolated E. coli were cultured on Mueller-Hinton agar and antibiotic susceptibility was tested by Kirby-Bauer disk diffusion method following the Clinical and Laboratory Standard Institute 2017 guidelines.ResultsESBL-producing samples had higher antibiotic resistance rates than ESBL-non-producing samples: ceftriaxone (58.8% vs. 27.3%), cefotaxime (73.5% vs. 30.3%), ceftizoxime (76.5% vs. 33.3%), cefixime (79.4% vs. 40.9%), and cefpodoxime (73.5% vs. 53%), except for carbenicillin (29.4% vs. 48.5%). Imipenem and meropenem were the least resisted antibiotics in ESBL-producing samples (5.9% and 11.8%).ConclusionESBL-producing Enterobacteriaceae have a high resistance rate to third-generation cephalosporins and high susceptibility to imipenem and meropenem.Copyright: © 2019 Journal of Research in Medical Sciences.

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