• J Res Med Sci · Jan 2020

    Risk factors of the efficacy of hepatitis B vaccine in health-care workers.

    • Hassan Salehi, Marzieh Salehi, Nader Kalbasi, Maryam Salehi, Jalil Sharifian, and Mohammad Mahdi Salehi.
    • Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    • J Res Med Sci. 2020 Jan 1; 25: 15.

    BackgroundConventional hepatitis B virus vaccination fails to achieve efficient protection in about 5%-10% of the world population. Different factors influence the immunogenicity of hepatitis B vaccine. This study aimed to evaluate these factors in health-care workers.Materials And MethodsThis was a descriptive study which was implemented among 140 of medical and dental staff working as health-care workers who were low responder after vaccination entered the study.ResultsAge (>40 years), weight (body mass index >25), immunodeficiency diseases, (primary immune deficiency and immunosuppressant drugs), diabetes mellitus, and smoking were the important factors.ConclusionIn the high-risk group of hepatitis B disease, the risk factors of immunogenicity must be evaluated at vaccination and check titers of antibody after vaccination.Copyright: © 2020 Journal of Research in Medical Sciences.

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