• Neurology · Jun 2014

    Comparative Study

    Abnormal thalamic function in patients with vestibular migraine.

    • Antonio Russo, Vincenzo Marcelli, Fabrizio Esposito, Virginia Corvino, Laura Marcuccio, Antonio Giannone, Renata Conforti, Elio Marciano, Gioacchino Tedeschi, and Alessandro Tessitore.
    • From the Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences (A.R., L.M., G.T., A.T.) and MRI Research Center SUN-FISM (A.R., R.C., G.T., A.T.), Second University of Naples; Institute for Diagnosis and Care Hermitage Capodimonte (A.R.), Naples; Department of Neuroscience (V.M., V.C., A.G., E.M.), University of Naples Federico II, Naples; Department of Medicine and Surgery (F.E.), University of Salerno, Baronissi (SA), Italy; and Department of Cognitive Neuroscience (F.E.), Maastricht University, the Netherlands.
    • Neurology. 2014 Jun 10; 82 (23): 2120-6.

    ObjectiveTo investigate the functional response of neural pathways associated with vestibular stimulation in patients with vestibular migraine (VM).MethodsTwelve patients with VM underwent whole-brain blood oxygen level-dependent (BOLD) fMRI during ear irrigation with cold water. The functional response of neural pathways to this stimulation in patients with VM was compared with age- and sex-matched patients with migraine without aura and healthy controls. Secondary analyses explored associations between BOLD signal change and clinical features of migraine in patients.ResultsWe observed a robust cortical and subcortical pattern of BOLD signal change in response to ear irrigation across all participants. Patients with VM showed a significantly increased thalamic activation in comparison with both patients with migraine without aura and healthy controls. The magnitude of thalamic activation was positively correlated with the frequency of migraine attacks in patients with VM.ConclusionsWe provide novel evidence for abnormal thalamic functional response to vestibular stimulation in patients with VM. These functional abnormalities in central vestibular processing may contribute to VM pathophysiology.© 2014 American Academy of Neurology.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…