• Ali Furkan Batur, Muhammed Furkan Aydogan, Ozcan Kilic, Muslu Kazım Korez, Murat Gul, Mehmet Kaynar, Serdar Goktas, and Murat Akand.
• Department of Urology, Selcuk University School of Medicine, Konya, Turkey.
• Int. J. Clin. Pract. 2021 Apr 1; 75 (4): e13743.

ObjectiveTo investigate the clinical value of preoperative De Ritis ratio (aspartate aminotransferase/alanine aminotransferase) (DRR) in patients with transitional cell bladder cancer (TCBC) at initial diagnosis. The secondary objective was to investigate the status of systemic inflammatory parameters, such as neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), platelet-lymphocyte ratio (PLR) and platelet-monocyte ratio (PMR).Materials And MethodsThe records of patients with primary TCBC who underwent transurethral resection were retrospectively evaluated. The relationship of DRR and systemic inflammatory parameters with clinicopathological findings, recurrence and progression status was evaluated separately.ResultsThere was no significant difference in the DRR according to the clinicopathological findings, recurrence and progression. Significant differences were found between the NLR and the patient groups for tumour diameter, tumour stage, tumour grade and progression. In univariate analysis, the LMR was found to be associated with progression, and also the PLR and LMR were found to be associated with recurrence. Decrease in LMR and increase in LMR score demonstrated by multiple analysis was shown as independent predictors of progression and recurrence development.ConclusionsThis paper shows a positive correlation between poor prognosis in TCBC and the systemic inflammatory markers, namely NLR, LMR, PLR and PMR, but not DRR.© 2020 John Wiley & Sons Ltd.

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