• Abdalwhab Zwiri, Manal Ahmad Alrawashdeh, Mohammad Khan, Wan Muhamad Amir W Ahmad, Nur Karyatee Kassim, Jawaad Ahmed Asif, Khoo Suan Phaik, Adam Husein, and Zuryati Ab-Ghani.
• School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia.
• Pain Res Manag. 2020 Jan 1; 2020: 5971032.

ObjectiveThe aim of this systematic review was to evaluate the effectiveness of laser application in temporomandibular joint disorder.MethodsPubMed, SCOPUS, Science Direct, Web of Science, and Google Scholar electronic databases were searched systematically with restricting the languages to only English and year (January 2001 to March 2020), and studies were selected based on the inclusion criteria. Study quality and publication bias were assessed by using the Robvis, a software package of R statistical software.ResultsThis systematic review included 32 studies (1172 patients) based on the inclusion and exclusion criteria. Most of the studies reported significant reduction of pain by the use of the laser during TMD treatment. Two-thirds of the study (78.13%) found a better outcome comparing with conventional one. According to Robvis, 84.4% of the studies were high methodological studies with low risk of bias.ConclusionTMD patients suffer with continuous pain for long time even after conventional treatment. Laser therapy shows a promising outcome of pain reduction for TMD patients. Therefore, laser therapy can be recommended for the TMD patients' better outcome. This trial is registered with PROSPERO (CRD42020177562).Copyright © 2020 Abdalwhab Zwiri et al.

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