• Yuehan Wang, Duck-Chul Lee, Angelique G Brellenthin, EijsvogelsThijs M HTMHDepartment of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands., Xuemei Sui, Timothy S Church, Carl J Lavie, and Steven N Blair.
• Department of Kinesiology, Iowa State University, Ames, IA; Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands.
• Am. J. Med. 2019 Oct 1; 132 (10): 122512321225-1232.

ObjectivesWe examined the overall association as well as the dose-response relationship between leisure-time running and incident type 2 diabetes.MethodsParticipants were 19,347 adults aged 18-100 years who were free of cardiovascular disease, cancer, and diabetes at baseline, and who received at least 2 extensive preventive medical examinations between 1974 and 2006. Running and other types of aerobic physical activity were assessed by self-reported leisure-time activities. Type 2 diabetes was defined as fasting glucose ≥126 mg/dL (7.0 mmol/L), physician diagnosis, or insulin use.ResultsDuring an average follow-up of 6.5 years, 1015 adults developed type 2 diabetes. Approximately 29.5% of adults participated in leisure-time running at baseline. Runners had a 28% (hazard ratio [HR] 0.72; 95% confidence interval [CI], 0.62-0.84) lower risk of developing type 2 diabetes compared with nonrunners during follow-up. The HRs (95% CIs) of type 2 diabetes were 0.98 (0.75-1.28), 0.69 (0.51-0.92), 0.62 (0.45-0.85), 0.78 (0.59-1.04), and 0.57 (0.42-0.79) across quintiles of running time (minutes/week) compared with nonrunners after adjusting for potential confounders, including levels of nonrunning aerobic physical activity. Similar dose-response relationships between running distance (miles/week), frequency (times/week), total amount (MET-minutes/week), and speed (mph) were also observed.ConclusionsParticipating in leisure-time running is associated with a lower risk of developing type 2 diabetes in adults. Consistent linear dose-response relationships were observed between various running parameters and incident type 2 diabetes, supporting the prescription of running to prevent type 2 diabetes.Copyright © 2019 Elsevier Inc. All rights reserved.

25 keywords...

hide…