• Nakhshab Choudhry, Sana Sarmad, Noor Ul Ain Waheed, and Aamir Jamal Gondal.
• Prof. Dr. Nakhshab Choudhry, PhD. Department of Biochemistry, King Edward Medical University, Lahore, Pakistan.
• Pak J Med Sci. 2019 Jan 1; 35 (1): 252-256.

ObjectiveTo estimate the serum levels of matrix metalloproteinases in oral squamous cell carcinoma patients and in healthy subjects.MethodsIn this observational study, biopsy diagnosed oral squamous cell carcinoma patients (n= 38) were recruited from Mayo Hospital, Lahore during 2016 to 2017. Age and gender matched Controls (n= 38) were also included. Venous blood sample of each participant was drawn, serum separated and the levels of matrix metalloproteinases were measured by multiplex ELISA.ResultsSerum levels of MMP-1, -8, -10, -12 and -13 in OSCC patients showed statistically significant increase as compared to control group (p < 0.01). The MMP-12 predicted the presence of OSCC with highest AUC of 0.836 (95% CI [0.733 to 0.911]) for sensitivity and specificity of 80% and 78.9%, respectively for a cut-off value of 16.13 pg/ml.ConclusionsMMP-12 has been found to have significant sensitivity and specificity to qualify as a diagnostic biomarker.

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