• Jing Li, Jinzhi Ji, Fuyan Liu, and Lingling Wang.
• Jing Li General Medicine (I), Binzhou People's Hospital, Shandong, 256610, China.
• Pak J Med Sci. 2019 Jan 1; 35 (3): 609-613.

ObjectiveTo investigate the clinical efficacy of insulin glargine combined with acarbose in the treatment of elderly patients with diabetes.MethodsOne hundred and forty-four elderly patients with diabetes who received treatment between December 2016 and December 2017 in Binzhou People's Hospital, China, were selected and divided into a control group and an observation group, 72 each, using random number table. The control group was treated with insulin glargine, while the observation group was treated with insulin glargine combined with acarbose. The therapeutic effect, improvement of quality of life and adverse reactions were compared between the two groups.ResultsAfter treatment, fasting blood glucose (FBG), 2h postprandial blood glucose (PBG) and glycosylated hemoglobin (Hb Alc) of the two groups were lower than those before treatment, and the decrease degree of the observation group was significantly larger than that of the control group (P<0.05). The time needed for blood glucose reaching the standard level and daily insulin dosage of the observation group were significantly lower than that of the control group, and the differences were statistically significant (P<0.05). SF-36 scale score of the observation group was significantly better than the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).ConclusionThe combination of insulin Glargine and Acarbose can significantly control the blood glucose level of elderly patients with diabetes, improve the biochemical indicators, and enhance the quality of life. It is worth promotion in clinical practice.

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