• Julie M Fritz, Elizabeth Lane, Molly McFadden, Gerard Brennan, John S Magel, Anne Thackeray, Kate Minick, Whitney Meier, and Tom Greene.
• College of Health, University of Utah, Salt Lake City, Utah (J.M.F.).
• Ann. Intern. Med. 2021 Jan 1; 174 (1): 8-17.

BackgroundFew studies have examined primary care management for acute sciatica, including referral to physical therapy.ObjectiveTo evaluate whether early referral to physical therapy reduced disability more than usual care (UC) alone for patients with acute sciatica.DesignRandomized controlled clinical trial. (ClinicalTrials.gov: NCT02391350).Setting2 health care systems in Salt Lake City, Utah.Patients220 adults aged 18 to 60 years with sciatica of less than 90 days' duration who were making an initial primary care consultation.InterventionAll participants received imaging and medication at the discretion of the primary care provider before enrollment. A total of 110 participants randomly assigned to UC were provided 1 session of education, and 110 participants randomly assigned to early physical therapy (EPT) were provided 1 education session and then referred for 4 weeks of physical therapy, including exercise and manual therapy.MeasurementsThe primary outcome was the Oswestry Disability Index (OSW) score after 6 months. Secondary outcomes were pain intensity, patient-reported treatment success, health care use, and missed workdays.ResultsParticipants in the EPT group had greater improvement from baseline to 6 months for the primary outcome (relative difference, -5.4 points [95% CI, -9.4 to -1.3 points]; P = 0.009). The OSW and several secondary outcomes favored EPT after 4 weeks. After 1 year, between-group differences favored EPT for the OSW (relative difference, -4.8 points [CI, -8.9 to -0.7 points]) and back pain intensity (relative difference, -1.0 points [CI, -1.6 to -0.4 points]). The EPT group was more likely to self-report treatment success after 1 year (45.2%) than the UC group (27.6%) (relative risk, 1.6 [CI, 1.1 to 2.4]). There were no significant differences in health care use or missed workdays.LimitationThe patients and providers were unblinded, and specific physical therapy interventions responsible for effects could not be determined.ConclusionReferral from primary care to physical therapy for recent-onset sciatica improved disability and other outcomes compared with UC.Primary Funding SourceAgency for Healthcare Research and Quality.

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