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- I Papakonstantinou and I Poulakidas.
- 1 Department of Internal Medicine, 401 General Military Hospital of Athens, Greece401 General Military Hospital of Athens, Greece.
- Hippokratia. 2014 Oct 1; 18 (4): 370-2.
BackgroundSevere immune thrombocytopenia displays a rare side effect of pegylated interferon therapy for Hepatitis C infection. Our aim is to report a case of severe and late onset immune thrombocytopenia due to pegylated interferon treatment that was effectively managed with the anti-CD20 monoclonal antibody Rituximab.Description Of The CaseA 27-year-old male, Hepatitis C infected patient, presented with sudden, severe immune thrombocytopenia at the end of a standard 24-week antiviral treatment, as a side effect of pegylated interferon. Platelet count rapidly normalized with Rituximab infusions.ConclusionRituximab could be a valuable treatment option in pegylated interferon related immune thrombocytopenia, when patients are resistant to conventional treatment or when physicians are reluctant to administer corticosteroids.
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