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Pediatric emergency care · Oct 2020
Case ReportsThe Not-So-Soft Spot: Pathophysiology of the Bulging Fontanelle in Association With Roseola.
- Thomas Cristoforo, Nicole K Le, Summer Rye-Buckingham, William B Hudson, and Leslie F Carroll.
- Morsani College of Medicine, University of South Florida, Tampa, FL.
- Pediatr Emerg Care. 2020 Oct 1; 36 (10): e576-e578.
AbstractRoseola infantum is a clinical syndrome characterized by high fever followed by the emergence of a rash. Case reports have documented an association between bulging fontanelles and roseola. We propose a novel mechanism for the development of intracranial hypertension caused by human herpesvirus 6-induced cytokine elevation leading to increased cerebrospinal fluid production.
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