• Chun-Wei Ho, Hsin-Hung Chen, Ming-Chia Hsieh, Ching-Chu Chen, Sheng-Pang Hsu, Hei-Tung Yip, and Chia-Hung Kao.
• Intelligent Diabetes Metabolism and Exercise Center, China Medical University Hospital, Taichung 40447 Taiwan.
• Int J Environ Res Public Health. 2020 Apr 2; 17 (7).

ObjectiveTo investigate the prevalence of polycystic ovary syndrome (PCOS) and its comorbidities in patients with autoimmune thyroid disease (AITD).PopulationIn this cohort study, patients newly diagnosed as having Hashimoto thyroiditis (HT) or Grave disease (GD) were recruited into the AITD group.MethodThe logistic regression model was used to investigate the association between exposure, endpoint, later diseases and treatment.Main Outcome MeasuresWe assessed the cumulative incidence using the Kaplan-Meier method and verified the difference by the log-rank test.ResultsThe AITD group included 3599 GD patients and 1332 HT patients. PCOS risk in patients with AITD was higher than that in the control group (adjusted hazard ratio = 1.39; 95% confidence interval = 1.07-1.71). In patients with both AITD and PCOS, the odds ratios of diabetes, hyperlipidemia and coronary artery disease were 2.48, 2.05 and 2.63, respectively.ConclusionsThe risks of PCOS and its comorbidities such as diabetes, dyslipidemia and cardiac artery disease are high in patients with AITD in Taiwan.

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