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Case Reports Comparative Study
Stimulated single-fiber electromyography in Lambert-Eaton myasthenic syndrome.
- V Chaudhry, D F Watson, S J Bird, and D R Cornblath.
- Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
- Muscle Nerve. 1991 Dec 1; 14 (12): 1227-30.
AbstractThe Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder of neuromuscular transmission. Electrodiagnosis is confirmed by an increase in compound muscle action potential amplitude during high-frequency repetitive nerve stimulation or following brief exercise. We describe the results of stimulated single-fiber electromyography in 4 patients with disorders of neuromuscular transmission: LEMS (2), LEMS/myasthenia gravis (MG) overlap (1), and MG (1). Stimulated SFEMG was performed in the extensor digitorum communis muscle with axonal intramuscular suprathreshold stimulation at low and high rates. In all 4 patients, a rate dependence of jitter was found. In LEMS and LEMS/MG, jitter and blocking improved with high stimulation rates, as compared with the opposite effect in MG. We conclude that stimulated SFEMG is a valuable technique in the diagnosis of LEMS.
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