• İbrahim Önder Yeniçeri, Fatih Mehmet Azık, and Funda Dinç Elibol.
• Department of Radiology, School of Medicine, Muğla Sıtkı Koçman University, Muğla, Turkey
• Turk J Med Sci. 2021 Apr 30; 51 (2): 583-588.

Background/AimThe aim of this study was to evaluate the intraobserver and interobserver reliability of cardiac T2* MRI measurements in different region of interest (ROI) sizes.Materials And MethodsCardiac T2* MRIs of 24 thalassemia major patients were evaluated. Two different ROI sizes were used for measurement. In the first measurement, an ROI approximately 5 mm in diameter was used in the interventricular septal myocardium. In the other method, the whole ventricular septal myocardium was used as the measurement. The intraobserver and interobserver variabilities were assessed with the intraclass correlation coefficient (ICC).ResultsThe measurement of the first observer, the ICC of the small-sized ROI (ssROI), was 0.869, and the measurement for the second observer, the ICC of the ssROI, was 0.659. The ICC of the whole-septal ROI (wsROI) was 0.991 for the first observer and 0.980 for the second observer. Interobserver variability, for the mean measurement, was 0.442 for the ICC of ssROI and 0.883 for the ICC of wsROI.ConclusionFor the evaluation of myocardial iron load with T2* MRI we suggest making measurements with ROI, including all of the interventricular septum, as a consequence of high intraobserver and interobserver consistency.This work is licensed under a Creative Commons Attribution 4.0 International License.

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