• Gary Duclos, Adrien Rivory, Noémie Rességuier, Emmanuelle Hammad, Coralie Vigne, Zoé Meresse, Bruno Pastène, Xavier-Benoit D'journo, Samir Jaber, Laurent Zieleskiewicz, and Marc Leone.
• Aix Marseille University, Assistance Publique Hôpitaux de Marseille, Nord Hospital, Department of Anesthesiology and Critical Care, Marseille, France. Electronic address: garyduclos@ap-hm.fr.
• J Crit Care. 2021 Jun 1; 63: 179-186.

PurposeOur study aimed to explore the association between early hyperoxemia of the first 24 h on outcomes in patients with severe blunt chest trauma.Materials And MethodsIn a level I trauma center, we conducted a retrospective study of 426 consecutive patients. Hyperoxemic groups were classified in severe (average PaO2 ≥ 200 mmHg), moderate (≥150 and < 200 mmHg) or mild (≥ 100 and < 200 mmHg) and compared to control group (≥60 and < 100 mmHg) using a propensity score based analysis. The first endpoint was the incidence of a composite outcome including death and hospital-acquired pneumonia occurring from admission to day 28. The secondary endpoints were the incidence of death, the number of hospital-acquired pneumonia, mechanical ventilation-free days and intensive care unit-free day at day 28.ResultsThe incidence of the composite endpoint was lower in the severe hyperoxemia group(OR, 0.25; 95%CI, 0.09-0.73; P < 0.001) compared with control. The 28-day mortality incidence was lower in severe (OR, 0.23; 95%CI, 0.08-0.68; P < 0.001) hyperoxemia group (OR, 0.41; 95%CI, 0.17-0.97; P = 0.04). Significant association was found between hyperoxemia and secondary outcomes.ConclusionIn our cohort early hyperoxemia during the first 24 h of admission after severe blunt chest trauma was not associated with worse outcome.Copyright © 2020. Published by Elsevier Inc.

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