• Anna Albert, Tanja Stüber, Jonas Bauer, and Achim Wöckel.
• Dtsch. Med. Wochenschr. 2020 Oct 1; 145 (20): 1460-1463.

IntroductionBreast cancer is the most frequently diagnosed type of cancer in women and there are continuously new findings in research for further treatment approaches.Early DiagnosisMammography is already a well-established prevention method in Germany for women aged 50-69, reducing mortality rates significantly. The benefit of extending the screening period including women older than 70 years has been proven recently. Intensive research in hereditary breast cancer makes it possible to identify high risk patients and include them to a more frequent screening program with additional MRI.TherapyIn early as well as in advanced stages of breast cancer the treatment should be as targeted and as noninvasive as possible. After neoadjuvant therapy a mastectomy is needed less frequently and axillary lymph node dissection can be limited to rare cases. Molecular subtyping allows more individualized treatment in curative and palliative intention.Reconstructive SurgeryBIA-ALCL is an uncommon and highly treatable T-cell lymphoma associated with textured silicone or saline filled breast implants. Despite increasing incidence the usage of those implants is possible - but only after adequate information.Follow UpDue to new insights into the biology of breast cancer the period of follow-up care has been expanded to ten years.OutlookThe detection of an ESR1 mutation could possibly be used as a predictive marker regarding endocrine therapy in the future. Furthermore, there are promising results for blocking the PD-1 axis in primary systemic chemotherapy for triple-negative breast cancer.Thieme. All rights reserved.

23 keywords...

hide…