• J Am Coll Emerg Physicians Open · Jun 2020

    Clinical, laboratory, and radiological features indicative of novel coronavirus disease (COVID-19) in emergency departments - a multicentre case-control study in Hong Kong.

    • LamRex Pui KinRPKEmergency Medicine Unit Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong Special Administrative Region China.Accident and Emergency Department Queen Mary Hospital Hong Kong Special Administrative Region China.Accident, Kevin Kei Ching Hung, Eric Ho Yin Lau, Chun Tat Lui, Kin Ling Chan, Chin San Leung, Ion Wa Wong, Kin Wa Wong, Colin A Graham, and Patrick Chiu Yat Woo.
    • Emergency Medicine Unit Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong Special Administrative Region China.
    • J Am Coll Emerg Physicians Open. 2020 Jun 20.

    ObjectivesLittle is known about the value of routine clinical assessment in identifying patients with coronavirus disease 2019 (COVID-19) in the emergency department (ED). We aimed to compare the exposure history, signs and symptoms, laboratory, and radiographic features of ED patients who tested positive and negative for COVID-19.MethodsThis was a case-control study in seven EDs in Hong Kong from 20 January to 29 February 2020. Thirty-seven patients with laboratory-confirmed COVID-19 were age- and gender-matched to 111 controls. We compared the groups with univariate analysis and calculated the odds ratio (OR) of having COVID-19 for each characteristic that was significantly different between the groups with adjustment for age and presumed location of acquiring the infection.ResultsThere were no significant differences in patient characteristics and reported symptoms between the groups. A positive contact history within 14 days (adjusted OR 37.61, 95% CI 10.86-130.19), bilateral chest radiograph shadow (adjusted OR 13.19, 95% CI 4.66-37.35), having prior medical consultation (adjusted OR 7.43, 95% 2.89 -19.09), a lower white blood cell count (adjusted OR 1.30, 95% CI 1.11-1.51), and a lower platelet count (adjusted OR 1.07, 95% CI 1.01-1.12) were associated with a higher odds of COVID-19 separately. A higher neutrophil count was associated with a lower odds of COVID-19 (adjusted OR 0.77, 95% CI 0.65-0.91).ConclusionThis study highlights a number of clinical features that may be useful in identifying high-risk patients for early testing and isolation while waiting for the test result. Further studies are warranted to verify the findings.This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

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