• Oktay Bilgir, Ferda Bilgir, Levent Kebapcilar, Giray Bozkaya, Mehmet Çalan, Halil Kırbıyık, Meltem Avci, İsmail Sari, Arif Yuksel, and Tolgay Isikyakar.
• Department of Internal Medicine, Izmir Bozyaka Research and Training Hospital, 35380 Bozyaka, Izmir, Turkey. obilgir2001@yahoo.com
• Transfus Apher Sci. 2012 Feb 1; 46 (1): 19-24.

BackgroundThe purpose of this study is to determine the levels of procalcitonin (PCT), IL-8 (interleukin-8), MIF (macrophage migration inhibitory factor), osteoprotegerin (OPG), hs-CRP and D-dimer during fever above 38.3°C due to various causes.Material And MethodsBlood samples taken from a total of consecutive 65 hospitalized patients during fever were prospectively tested for hsCRP, PCT, IL-8, OPG, MIF and D-dimer. Of these patients, there were 26 patients presenting with chemotherapy-induced neutropenia who had no infectious agents found; 23 patients, who had a malignancy with a febrile episode which was neither a microbiologically documented infection nor a chemotherapy-induced neutropenia, and 16 patients who did not have a malignancy and were considered to have a clinically and microbiologically documented infection.ResultsIL-8 and D-dimer levels were higher in patients with febrile neutropenia than in the other two groups. Although MIF and OPG were higher in patients with newly diagnosed cancers, there were no differences among the three groups regarding PCT and hs-CRP values.ConclusionHigh serum IL-8 and D-dimer levels can be useful markers to identify hospitalized chemotherapy-induced neutropenia patients. MIF and OPG were found to be higher in patients with newly diagnosed cancer.Copyright © 2011 Elsevier Ltd. All rights reserved.

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