• Journal of critical care · Feb 2021

    Safety and efficacy of vasopressor administration through midline catheters.

    • Nivedita Prasanna, David Yamane, Naeha Haridasa, Danielle Davison, Andrew Sparks, and Katrina Hawkins.
    • Department of Anesthesiology and Critical Care, George Washington University Hospital, Washington D.C., USA. Electronic address: niveditaprasanna21@gmail.com.
    • J Crit Care. 2021 Feb 1; 61: 1-4.

    ContextVasopressors are commonly administered through Central Venous Catheters (CVCs) as it is considered unsafe to administer them via peripheral IVs, mainly due to the concern of local tissue injury. Unlike peripheral IVs, midline catheters provide a wider lumen with the catheter tip ending in a large peripheral vein. The use of vasopressors through midline catheters has not yet been evaluated.ObjectiveThe primary objective of this study is to determine the safety and efficacy of long term administration of vasopressors through a midline catheter.DesignThis is a retrospective study between 2016 and 2019 looking at the outcomes of midline catheters.Setting45 bed Tertiary level ICU in a 600-bed teaching hospital.PatientsA total of 248 patients received vasopressors via midline catheters.ResultsThe average midline dwell time was 14.7 ± 12.8 days and the average duration of continuous vasopressor infusion was 7.8 ± 9.3 days. Vasopressors used with their average dose (AD) were norepinephrine (n = 165, 16.8 CE ± 10.7 μg/min), epinephrine (n = 56, 9.1 CE ± 6.0 μg/min), vasopressin (n = 123, 0.05 CE ± 0.02 units/min), phenylephrine (n = 158, 91.4 CE ± 64.7 μg/min) and Angiotensin II (50 CE ± 27.6 ng/kg/min). Early Complication rate was 3.6% due to Bloodstream infection (n = 6), drug extravasation (n = 1), thrombophlebitis (n = 1) and arterial puncture (n = 1). Late Complication rate was 0.8% (n = 2) due to midline-associated DVTs. There were no complications related to ineffective drug delivery or limb endangerment.ConclusionsMany medical centers are attempting to limit the use of central venous catheters (CVCs) to avoid central line-associated bloodstream infections (CLABSIs). This study demonstrates that midline catheters are a safe alternative to CVCs, for the safe and efficacious administration of vasopressors for prolonged periods of time.Copyright © 2020 Elsevier Inc. All rights reserved.

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