• A Thalme, A T Nygren, I Julander, and U Freyschuss.
• Department of Infectious Diseases, Huddinge University Hospital, Sweden.
• Scand. J. Infect. Dis. 1996 Jan 1; 28 (4): 407-10.

AbstractA sensitive, specific, and rapid diagnosis of infective endocarditis (IE) is important for prognosis, and to exclude IE and thus avoid prolonged treatment with antibiotics. The diagnostic system for IE according to Duke's university includes echocardiographic results and classifies patients in 3 categories--'definite', 'possible', and 'rejected'--by combining pathologic, echocardiographic, clinical, and blood culture findings. Transesophageal echocardiography (TEE) has better diagnostic sensitivity compared to transthoracic echocardiography. Duke's criteria were used on 83 patients examined by TEE in a retrospective study. Of 83 patients with suspected IE, 49 episodes in 48 patients were classified as 'rejected' and were not treated. The remaining 37 patients (15 of whom were intravenous drug users) were treated and classified as follows: 'definite', 26 episodes in 24 patients, 'possible', 11 episodes in 11 patients; and 'rejected', 2 episodes in 2 patients. In this retrospective analysis Duke's criteria were easy to apply. A negative TEE made IE unlikely and a positive TEE made IE probable when other signs of infection were present.

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