• Immunol Allergy Clin North Am · Nov 2020

    Review

    Targeting Mast Cells with Biologics.

    • Jonathan J Lyons and Dean D Metcalfe.
    • Translational Allergic Immunopathology Unit, Laboratory of Allergic Diseases, National Institutes of Health, 9000 Rockville Pike, Building 29B, Room 5NN18, MSC 1889, Bethesda, MD 20892, USA. Electronic address: jonathan.lyons@nih.gov.
    • Immunol Allergy Clin North Am. 2020 Nov 1; 40 (4): 667-685.

    AbstractMast cells are tissue-resident allergic effector cells that cause many symptoms associated with IgE-mediated immediate hypersensitivity reactions. Beginning with allergen-specific therapy over a century ago, biologics have been used to target mast cells in patients in order to reduce allergic symptoms and reactions. This review discusses the history and current outlook of the use of biologics in mast cell-associated diseases and reactions.Published by Elsevier Inc.

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