The role of aspirin as antiaggregant therapy in primary

Medicina clinica · Oct 2019

Review

The role of aspirin as antiaggregant therapy in primary prevention. An update.

Aspirin indication in primary prevention has been questioned in the last ten years due to the publication of several trials with neutral outcomes. In the last year, three research studies discussed in this review (ASCEND, ARRIVE, ASPREE) have weighed the benefit (cardiovascular events reduction) against the adverse effects (especially bleeding) in several situations such as general population with moderate cardiovascular risk, diabetics and elderly population. This review performs a detailed analysis of these trials and it also comments on a recent metanalysis that includes these projects along with others undertaken in the last 30 years. In addition, the current position of aspirin in primary prevention is established based on the latest evidence reviewed.

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- Nicolás Jiménez-García, Javier de la Torre Lima, and Javier García Alegría.
- Servicio de Medicina Interna, Agencia Sanitaria Costa del Sol, Marbella, Málaga, España. Electronic address: nijimenez93@gmail.com.
- Med Clin (Barc). 2019 Oct 25; 153 (8): 326-331.
AbstractAspirin indication in primary prevention has been questioned in the last ten years due to the publication of several trials with neutral outcomes. In the last year, three research studies discussed in this review (ASCEND, ARRIVE, ASPREE) have weighed the benefit (cardiovascular events reduction) against the adverse effects (especially bleeding) in several situations such as general population with moderate cardiovascular risk, diabetics and elderly population. This review performs a detailed analysis of these trials and it also comments on a recent metanalysis that includes these projects along with others undertaken in the last 30 years. In addition, the current position of aspirin in primary prevention is established based on the latest evidence reviewed.Copyright © 2019 Elsevier España, S.L.U. All rights reserved.

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The role of aspirin as antiaggregant therapy in primary prevention. An update.

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