• Curr. Opin. Infect. Dis. · Aug 2013

    Review

    Community-acquired respiratory viral infections in lung transplant recipients.

    • Sarah Shalhoub and Shahid Husain.
    • Department of Medicine, Division of Multiorgan Transplant Infectious Diseases, University of Toronto, Toronto, Ontario, Canada.
    • Curr. Opin. Infect. Dis. 2013 Aug 1; 26 (4): 302-8.

    Purpose Of ReviewCommunity-acquired respiratory virus (CARV) infections are a significant cause of morbidity and sometimes mortality in lung transplant recipients (LTRs); this review will focus on the most recent advances in this field.Recent FindingsRecent advancements in molecular diagnostics have resulted in the detection of higher rates of CARVs in LTRs. Persistence of rhinovirus has been implicated in the development of acute and chronic rejection, whereas the role of bocavirus remains uncertain. The data on the association of CARV infections with acute or chronic rejection remain less. A recent systematic review failed to show an association between CARV infections and acute or chronic rejection. Different routes of administration of antiviral medications, vaccines and newer promising antiviral medications are being evaluated to assess efficacy and safety. Similarly, newer strategies of vaccination may potentiate the immune response in these patients.SummaryWith current advanced investigating tools, the full impact of CARV infections in LTR is increasingly coming to realization. Research for novel effective treatments and improved responses to current and new vaccines is ongoing; they would provide great benefit in solving this complex and ever-evolving problem.

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