• J Clin Monit Comput · Dec 2021

    Non-linear regression analysis for estimating the intraoperative motor evoked potential recovery time after bolus neuromuscular blockade.

    • Tetsuro Tatsuoka, Tasuku Fujii, Takeshi Furuhashi, and Kimitoshi Nishiwaki.
    • Department of Information and Communication Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603, Japan. tatsuoka@cmplx.cse.nagoya-u.ac.jp.
    • J Clin Monit Comput. 2021 Dec 1; 35 (6): 1333-1339.

    AbstractThe recovery time of the motor evoked potential (MEP) amplitude following a neuromuscular blockade (NMB) during surgery is useful for interpreting low-amplitude waveforms or selecting the baseline waveform. In this study, the MEP data of 195 orthopedic cases who received a bolus dose of rocuronium at the beginning of surgery, between June 2009 and January 2016 were used. A non-linear regression analysis was applied to MEP amplitude data of multiple patients. The time taken for 90% of the maximum-amplitude recovery was estimated from the identified time series model. The 90% amplitude recovery time was 88.6 min in the pharmacological model and 89.4 min in the logistic model. These results were included in the 95% confidence interval of the previous studies. Although MEP amplitude is relatively unstable because of anesthesia, the averaged time series model of MEP amplitude can be estimated by using a large number of data.© 2020. Springer Nature B.V.

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