• Yukihiro Umeda, Yoshiki Demura, Miwa Morikawa, Shingo Ameshima, Tatsuro Tsuchida, Yasuhisa Fujibayashi, Hidehiko Okazawa, and Takeshi Ishizaki.
• Departments of Respiratory MedicineRadiologyBiomedical Imaging Research Center, University of Fukui, Fukui, Japan. umeda@u-fukui.ac.jp
• Respirology. 2011 May 1; 16 (4): 713-20.

Background And ObjectiveThe value of dual-time- point (18) F-FDG PET was investigated to predict the prognosis of patients with pulmonary sarcoidosis.MethodsTwenty-one patients with pulmonary sarcoidosis underwent (18) F-FDG PET examinations at two time points: an early scan at 60min and a delayed scan at 180min after injection of (18) F-FDG. Standardized uptake values (SUVs) at the two time points and the retention index (RI-SUV) calculated from these were evaluated. To evaluate disease progression, all patients underwent chest CT 1year after (18) F-FDG PET. Using these results, the accuracy of (18) F-FDG PET parameters and (67) Ga uptake for predicting disease persistence were compared, and the correlations between those parameters and serum markers were assessed.Results  RI-SUV was significantly higher in patients with increased or unchanged pulmonary lesions at follow-up CT (persistent group; 21.3±9.6%) than in patients with improved pulmonary lesions (improved group; -9.2±28.6%, P=0.0075). The diagnostic accuracy of RI-SUV in the persistent group was significantly greater than that of early SUV or (67) Ga uptake, and serum soluble IL-2 receptor showed a significant correlation with RI-SUV.ConclusionsRI-SUV showed better diagnostic accuracy compared with early SUV or (67) Ga uptake, in patients with persistent lung involvement at 1year. It may be a useful measure of persistent inflammation in patients with pulmonary sarcoidosis.© 2011 The Authors; Respirology © 2011 Asian Pacific Society of Respirology.

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