• J. Korean Med. Sci. · Oct 2020

    The Implication of Cardiac Injury Score on In-hospital Mortality of Coronavirus Disease 2019.

    • In Cheol Kim, Jin Eun Song, Hee Jung Lee, Jeong Ho Park, Miri Hyun, Ji Yeon Lee, Hyun Ah Kim, Yong Shik Kwon, Jae Seok Park, Jong Chan Youn, Jongmin Hwang, Cheol Hyun Lee, Yun Kyeong Cho, Hyoung Seob Park, Hyuck Jun Yoon, Chang Wook Nam, Seongwook Han, Seung Ho Hur, Howard J Eisen, and Hyungseop Kim.
    • Division of Cardiology, Department of Internal Medicine, Cardiovascular Center, Keimyung University Dongsan Hospital, Keimyung University College of Medicine, Daegu, Korea.
    • J. Korean Med. Sci. 2020 Oct 12; 35 (39): e349e349.

    BackgroundsThe severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has spread worldwide. Cardiac injury after SARS-CoV-2 infection is a major concern. The present study investigated impact of the biomarkers indicating cardiac injury in coronavirus disease 2019 (COVID-19) on patients' outcomes.MethodsThis study enrolled patients who were confirmed to have COVID-19 and admitted at a tertiary university referral hospital between February 19, 2020 and March 15, 2020. Cardiac injury was defined as an abnormality in one of the following result markers: 1) myocardial damage marker (creatine kinase-MB or troponin-I), 2) heart failure marker (N-terminal-pro B-type natriuretic peptide), and 3) electrical abnormality marker (electrocardiography). The relationship between each cardiac injury marker and mortality was evaluated. Survival analysis of mortality according to the scoring by numbers of cardiac injury markers was also performed.ResultsA total of 38 patients with COVID-19 were enrolled. Twenty-two patients (57.9%) had at least one of cardiac injury markers. The patients with cardiac injuries were older (69.6 ± 14.9 vs. 58.6 ± 13.9 years old, P = 0.026), and were more male (59.1% vs. 18.8%, P = 0.013). They showed lower initial oxygen saturation (92.8 vs. 97.1%, P = 0.002) and a trend toward higher mortality (27.3 vs. 6.3%, P = 0.099). The increased number of cardiac injury markers was significantly related to a higher incidence of in-hospital mortality which was also evidenced by Kaplan-Meier survival analysis (P = 0.008).ConclusionThe increased number of cardiac injury markers is related to in-hospital mortality in patients with COVID-19.© 2020 The Korean Academy of Medical Sciences.

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