• Joyce Chai, Edmund Hon, Chiu-Fai Li, Ting-Chung Pun, Shu-Biu Yeung, and Pak-Chung Ho.
• Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administrative Region, China. jchai@hkucc.hku.hk
• Eur. J. Obstet. Gynecol. Reprod. Biol. 2011 Sep 1; 158 (1): 72-5.

ObjectiveTo investigate the effectiveness of a single pre-operative dose of sublingual misoprostol on reducing blood loss in abdominal hysterectomies performed for symptomatic uterine leiomyomas.Study DesignA cohort of 64 women undergoing total abdominal hysterectomy for symptomatic uterine leiomyomas were randomly assigned to receive a single dose of sublingual 400 mcg misoprostol (n=32) or placebo containing 20mg vitamin B(6) (n=32) 30 min before the operation. The primary outcome was the operative blood loss. The secondary outcomes were requirement for blood transfusion, change in haemoglobin level after operation, and the incidence of side effects.ResultsWomen who had misoprostol were found to have similar operative blood loss to those who had placebo (570.9 ± 361.3 ml versus 521.4 ± 297.4 ml, for misoprostol and placebo group respectively; P=0.803). This study with a sample size of 64 was sufficient to have 80% power at the 5% level of significance to detect a reduction of blood loss greater than or equal to 30%. There were no observed differences in the need for post-operative blood transfusion (25% versus 15.6%, for misoprostol and placebo group respectively; P=0.536), the change in haemoglobin level after the operation, and the side effects profiles between the two groups.ConclusionA single pre-operative dose of sublingual misoprostol is not effective in reducing intra-operative blood loss and need for post-operative blood transfusion after total abdominal hysterectomies for symptomatic uterine leiomyomas.Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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