• Emilio Cendejas-Bueno, Iker Falces-Romero, María Laplaza-González, Luis Escosa-García, Cristina Schuffelmann-Gutierrez, María P Romero-Gómez, Cristina Verdú-Sánchez, Belén Calderón-Llopis, Irene Amores-Hernández, Javier Pemán, Ana Gómez-Zamora, Miguel Río-García, Juan José Menéndez-Suso, Diego Rodríguez-Álvarez, Iría Durán-Lorenzo, Elena Pérez-Acosta, Miguel Rodríguez Rubio, Elena Álvarez-Rojas, Paloma Dorao Martínez-Romillo, Federico Goded-Rambaud, de LorenzoAbelardo GarcíaAGIntensive Care Department, Hospital La Paz, Madrid, Spain., Emilio Maseda, Jesús Mingorance, Pedro de la Oliva, and Julio García-Rodríguez.
• Clinical Microbiology Department, Hospital La Paz, IdiPaz, Madrid, Spain.
• Pediatr Crit Care Me. 2021 Feb 1; 22 (2): e109-e114.

ObjectivesEarly diagnosis of invasive Candida infections is a challenge for pediatricians, intensivists, and microbiologists. To fill this gap, a new nanodiagnostic method has been developed using manual application of T2 nuclear magnetic resonance to detect Candida species. The aim of this study was to evaluate, prospectively, the usefulness as a tool diagnosis of the T2Candida panel in pediatric patients admitted at the PICU compared with blood culture.DesignThis is a prospective, observational, and unicentric study to compare T2Candida results with simultaneous blood cultures for candidemia diagnose.SettingThis study was carried out in a 1,300-bed tertiary care hospital with a 16-bed medical-surgical PICU.PatientsSixty-three patients from 0 to 17 years old were enrolled in this study, including those undergoing solid organ transplantation (kidney, liver, pulmonary, multivisceral, intestinal, and heart) and hematopoietic stem cell transplantation.Measurements And Main ResultsSeven patients were positive by the T2Candida test. Only two of them had the simultaneous positive blood culture. T2Candida yielded more positive results than blood cultures.ConclusionsT2Candida might be useful for the diagnosis of candidemia in PICUs. The prevalence of candidemia might be underestimated in this pediatric population. The use of this diagnostic tool in these units may help clinicians to start adequate and timely antifungal treatments.Copyright © 2020 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

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