• Qiang Luo, Lingli Zhang, Chu-Chung Huang, Yan Zheng, Jonathan W Kanen, Qi Zhao, Ye Yao, Erin B Quinlan, Tianye Jia, Tobias Banaschewski, BokdeArun L WALWDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Uli Bromberg, Christian Büchel, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, MartinotMarie-Laure PaillèreMPInstitute National de la Santé et de la Recherche Médicale Unit 1000, Neuroimaging and Psychiatry, University Paris Sud-Paris Saclay, University Paris Descartes, Paris, France.Assistance Publique-Hôpitaux de Paris, Department, Frauke Nees, OrfanosDimitri PapadopoulosDPNeuroSpin, Commissariat à L'énergie Atomique, Université Paris-Saclay, Gif-sur-Yvette, France., Luise Poustka, Sarah Hohmann, Juliane H Fröhner, Michael N Smolka, Henrik Walter, Robert Whelan, Barbara J Sahakian, Gunter Schumann, Fei Li, Jianfeng Feng, Sylvane Desrivières, Trevor W Robbins, and IMAGEN consortium.
• Institute of Science and Technology for Brain-Inspired Intelligence, Ministry of Education Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, People's Republic of China.
• Bmc Med. 2020 Oct 15; 18 (1): 278278.

BackgroundChildhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined.MethodsParticipants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were recruited. Voxel-based morphometry analysis of both childhood trauma and body mass index (BMI) was performed in the longitudinal IMAGEN cohort; validation of the findings was performed in the UKB. White-matter connectivity analysis was conducted to study the structural connectivity between the identified brain region and subdivisions of the hypothalamus in the HCP.ResultsIn IMAGEN, a smaller frontopolar cortex (FPC) was associated with both childhood abuse (CA) (β = - .568, 95%CI - .942 to - .194; p = .003) and higher BMI (β = - .086, 95%CI - .128 to - .043; p < .001) in male participants, and these findings were validated in UKB. Across seven data collection sites, a stronger negative CA-FPC association was correlated with a higher positive CA-BMI association (β = - 1.033, 95%CI - 1.762 to - .305; p = .015). Using 7-T diffusion tensor imaging data (n = 156), we found that FPC was the third most connected cortical area with the hypothalamus, especially the lateral hypothalamus. A smaller FPC at age 14 contributed to higher BMI at age 19 in those male participants with a history of CA, and the CA-FPC interaction enabled a model at age 14 to account for some future weight gain during a 5-year follow-up (variance explained 5.8%).ConclusionsThe findings highlight that a malfunctioning, top-down cognitive or behavioral control system, independent of genetic predisposition, putatively contributes to excessive weight gain in a particularly vulnerable population, and may inform treatment approaches.

22 keywords...

hide…