• I Ouanes, F Bouhaouala, S Maatouk, M Lahmar, S Ben Abdallah, Z Hammouda, F Dachraoui, L Ouanes-Besbes, E L'Her, and F Abroug.
• Service de Réanimation Polyvalente, Centre Hospitalo-Universitaire Fattouma Bourguiba, Monastir, Tunisia; Faculté de Médecine de Monastir, Université de Monastir, Tunisia. Electronic address: ouanes.islem@gmail.com.
• J Crit Care. 2021 Feb 1; 61: 45-51.

PurposeTo evaluate efficacy of FreeO2 device in oxygen weaning of patients after being liberated from mechanical ventilation (MV).MethodsProspective crossover cohort study in patients admitted to ICU and after MV weaning. FreeO2 curves were recorded during constant flow and FreeO2 modes. Oxygenation parameters and O2 consumption were assessed.ResultsFifty one records were obtained in 51 patients (median age, 62 years, 54.9% had COPD, admission for acute respiratory failure in 96%). NIV was used initially in 68.6%. For a median records duration of 2.04 h, the time spent within target SpO2 range was significantly higher with FreeO2 mode compared to constant O2 flow mode [86.92% (77.11-92.39) vs 43.17% (5.08-75.37); p < 0.001]. Time with hyperoxia was lower with FreeO2 mode: 8.68% (2.96-15.59) vs 38.28% (2.02-86.34). Times with hypoxaemia, and with severe desaturation, were similar. At the end of FreeO2 mode, O2 flow was lower than 1 l/min in 28 patients (54.9%), with a median of 0.99 l/min.ConclusionsFor the purpose of oxygen weaning in patients recovering from MV, automatic O2 titration with FreeO2 was associated with a substantial reduction in O2 delivery and better oxygenation parameters in comparison with constant O2 flow.Copyright © 2020 Elsevier Inc. All rights reserved.

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