• Gonzalo Sapisochin, Taizo Hibi, Christian Toso, Kwan Man, Marina Berenguer, Julie Heimbach, Tim F Greten, Trevor J Pugh, Laura A Dawson, and Vincenzo Mazzaferro.
• Multi-Organ Transplant and HPB Surgical Oncology, Division of General Surgery, University Health Network, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
• Ann. Surg. 2021 Mar 1; 273 (3): 483493483-493.

AbstractTransplant oncology defines any application of transplant medicine and surgery aimed at improving cancer patients' survival and/or quality of life. In practice, liver transplantation for selected hepato-biliary cancers is the only solid organ transplant with demonstrated efficacy in curing cancer. Four are the proposed future contributions of transplant oncology in hepato-biliary cancer (4-e). (1) evolutionary approach to cancer care that includes liver transplantation; (2) elucidation of self and non-self recognition systems, by linking tumor and transplant immunology; (3) exploration of innovative endpoints both in clinical and experimental settings taking advantage from the access to the entire liver explant; (4) extension of surgical limitation in the multidisciplinary approach to hepato-biliary oncology. The aim of this review is to define the principles of transplant oncology that may be applied to hepato-biliary cancer treatment and research, attempting to balance current evidences with future opportunities.Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

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