• Internal medicine · Sep 2021

    Case Reports

    A Case of Anti-LGI1 Encephalitis Developing Immunoglobulin Responsive Orthostatic Hypotension after Remission.

    • Kenta Orimo, Nobue K Iwata, Mizuho Kawai, Hideki Nakajima, Katsuhiko Takeda, Hiroyuki Murai, and Jun Goto.
    • Department of Neurology, International University of Health and Welfare Mita Hospital, Japan.
    • Intern. Med. 2021 Sep 15; 60 (18): 3021-3024.

    AbstractAnti-leucine-rich glioma-inactivated 1 (LGI1) antibody is associated with limbic encephalitis. We herein report a patient with anti-LGI1 encephalitis who developed severe orthostatic hypotension (OH) responsive to immunoglobulin therapy five years after developing symptoms of encephalitis. A 71-year-old man presented with amnesia caused by limbic encephalitis. The symptoms of encephalitis improved partially without any immunotherapy. Five years later, he developed severe OH, and anti-LGI1 antibody was positive. The catecholamine dynamics indicated that the central autonomic nervous system was the lesion of his OH. Intravenous immunoglobulin therapy improved the OH. This case suggests that anti-LGI1 antibody can be associated with severe OH.

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