• Rev Invest Clin · Jan 2020

    THE BRANCHED-CHAIN AMINO ACID TRANSAMINASE 1 -23C/G POLYMORPHISM CONFERS PROTECTION AGAINST ACUTE CORONARY SYNDROME.

    • Julian Ramírez-Bello, Gilberto Vargas-Alarcón, Óscar Pérez-Méndez, Marco A Martínez-Ríos, Marco A Peña-Duque, Guillermo Cardoso-Saldaña, Carlos Posadas-Romero, Mónica Sierra-Martínez, and José M Fragoso.
    • Research Unit, Hospital Juárez de México, Mexico City, Mexico.
    • Rev Invest Clin. 2020 Jan 1; 72 (1): 19-24.

    BackgroundPrevious studies have shown an association between polymorphisms of the BAT1-NF-κB inhibitor-like-1 (NFKBIL1)-LTA genomic region and susceptibility to myocardial infarction and acute coronary syndrome (ACS).ObjectiveThe objective of the study was to study the role of three polymorphisms in the BAT1, NFKBIL1, and LTA genes on the susceptibility or protection against ACS; we included a group of cases-controls from Central Mexico.MethodsThe BAT1 rs2239527C/G, NFKBIL1 rs2071592T/A, and LTA rs1800683G/A polymorphisms were genotyped using a 5' TaqMan assay in a group of 625 patients with ACS and 617 healthy controls.ResultsUnder a recessive model, the BAT1 -23C/G (rs2239527) polymorphism showed an association with protection against ACS (odds ratio = 0.56, and p-corrected = 0.019). In contrast, the genotype and allele frequencies of the NFKBIL1 rs2071592T/A and LTA rs1800683G/A polymorphisms were similar between ACS patients and controls and no association was identified.ConclusionOur data suggest an association between the BAT1 -23C/G polymorphism and protection against ACS in Mexican patients.Copyright: © 2019 Permanyer.

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