• Rev Invest Clin · Jan 2020

    Review

    STANDARD TREATMENT WITH BEVACIZUMAB AS TARGETED THERAPY IN CERVICAL CANCER.

    • Isabel Enríquez-Aceves, Tatiana Galicia-Carmona, Jaime A Coronel-Martínez, Raquel Espinosa-Romero, Germán Calderillo-Ruíz, Patricia Cortés-Esteban, and Lucely Cetina-Pérez.
    • Department of Medical Oncology, Hospital del Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), León, Gto., Mexico.
    • Rev Invest Clin. 2020 Jan 1; 72 (4): 213-218.

    AbstractMetastatic, recurrent, or persistent disease in cervical cancer has a poor prognosis. Historically, this group of patients has had limited treatment options, even with the best cytotoxic treatments (platinum-based chemotherapy [CT] doublets). Therefore, investigating new medications that help improve the patient's quality of life and survival has been essential. Angiogenesis has been shown to play a critical role in tumor cell growth and survival. Bevacizumab is a recombinant humanized monoclonal G1 immunoglobulin targeted against vascular endothelial growth factor. The combination of CT and bevacizumab is associated with an increase in overall survival as well as in progression-free survival and response rates.Copyright: © 2020 Permanyer.

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