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- Joerg Herold and Rupert Bauersachs.
- Klinikum Darmstadt, Klinik für Gefäßmedizin-Angiologie.
- Dtsch. Med. Wochenschr. 2020 Oct 1; 145 (21): 1562-1568.
AbstractRisks of thrombosis, bleeding and renal impairment are increasing with age. The efficacy and safety of the direct oral anticoagulants (DOACs) in fragile patients (age > 75 years and/or creatinine clearance levels < 50 ml/min and/or body weight below 50 kg) with indication for anticoagulation is one of the most challenging topic in cardiovascular medicine. New registry data from subgroup analyses of landmark studies and registries point towards to superiority of DOACs. This article summarizes new insights and describes pathways for anticoagulation in fragile patients.Thieme. All rights reserved.
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