• Baloglu Kaya Filiz F Eskisehir Osmangazi University, Faculty of Medicine, Department of Emergency Medicine, Buyukdere Mah, Prof. Dr. Nabi AVCI Bulvarı No: 4, 26040 Odunpa, Nurdan Acar, Engin Ozakin, Mustafa Emin Canakci, Caglar Kuas, and Muzaffer Bilgin.
• Eskisehir Osmangazi University, Faculty of Medicine, Department of Emergency Medicine, Buyukdere Mah, Prof. Dr. Nabi AVCI Bulvarı No: 4, 26040 Odunpazarı, Eskisehir, Turkey. Electronic address: fbaloglu@ogu.edu.tr.
• Am J Emerg Med. 2021 Mar 1; 41: 163-169.

AimWe aimed to compare regional cerebral oxygen saturation (rSO2) levels during cardiopulmonary resuscitation (CPR), performed either manually or using a mechanical chest compression device (MCCD), in witnessed cardiac arrest cases in the emergency department (ED), and to evaluate the effects of both the CPR methods and perfusion levels on patient survival and neurological outcomes.MethodsThis single-center, randomized study recruited patients aged ≥18 years who had witnessed a cardiopulmonary arrest in the ED. According to the relevant guidelines, CPR was performed either manually or using an MCCD. Simultaneously, rSO2 levels were continually measured with near-infrared spectroscopy.ResultsSeventy-five cases were randomly distributed between the MCCD (n = 40) and manual CPR (n = 35) groups. No significant difference in mean rSO2 levels was found between the MCCD and manual CPR groups (46.35 ± 14.04 and 46.60 ± 12.09, respectively; p = 0.541). However, a significant difference in rSO2 levels was found between patients without return of spontaneous circulation (ROSC) and those with ROSC (40.35 ± 10.05 and 50.50 ± 13.44, respectively; p < 0.001). In predicting ROSC, rSO2 levels ≥24% provided 100% sensitivity (95% confidence interval [CI] 92-100), and rSO2 levels ≥64% provided 100% specificity (95% CI 88-100). The area under the curve for ROSC prediction using rSO2 levels during CPR was 0.74 (95% CI 0.62-0.83).ConclusionA relationship between ROSC and high rSO2 levels in witnessed cardiac arrests exists. Monitoring rSO2 levels during CPR would be useful in CPR management and ROSC prediction. During CPR, MCCD or manual chest compression has no distinct effect on oxygen delivery to the brain.Trial Registrationclinicaltrials.gov identifier: NCT03238287.Copyright © 2020 Elsevier Inc. All rights reserved.

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