• Am. J. Ophthalmol. · Mar 2005

    Case Reports

    Phthisis bulbi caused by late congenital syphilis untreated until adulthood.

    • Kayo Uchiyama, Katsuma Tsuchihara, Takashi Horimoto, Tadahiro Karasawa, and Kazuhisa Sugiyama.
    • Department of Ophthalmology, Kanazawa Red Cross Hospital, Ishikawa, Japan. aoi729@kanazawa.nsk.ne.jp
    • Am. J. Ophthalmol. 2005 Mar 1; 139 (3): 545-7.

    PurposeTo report a case of phthisis bulbi resulting from late congenital syphilis untreated until adulthood.DesignObservational case report.MethodsWe report clinical and laboratory evaluations of a 43-year-old woman who presented with a palpebral ulcer of the right eye.ResultsThe patient had a gummatous palpebral ulcer and a phthisis bulbi in the right eye and a gumma on the left eyelid. A silent interstitial keratitis of the left eye was detected. The patient had hearing loss in the right ear, her nose was missing, and her right leg had been amputated. Treponemal pallidum hemagglutination (TPHA) test was positive. Although we administered intensive oral penicillin, the clinical symptoms of the patient did not improve.ConclusionsThis is a rare case of phthisis bulbi resulting from late congenital syphilis. We emphasize that treatment for late congenital syphilis must be carried out early and completely.

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