• Sayyed Gholamreza Mortazavi Moghaddam, Mohammad Hasan Namaei, Reza Eslami Manoochehri, and Mahmood Zardast.
• Department of Internal Medicine, Division of Pulmonary, School of Medicine, Vali-e-Asr Hospital, Birjand University of Medical Sciences, Birjand, Iran.
• J Res Med Sci. 2020 Jan 1; 25: 63.

BackgroundWe evaluated the sequential changes of interleukin (IL)-10 and IL-13 serum levels with tuberculosis (TB)-related radiographic changes during pulmonary TB (PTB) treatment.Materials And MethodsIn this cross-sectional study during two consecutive years, forty cases with PTB were recorded, and finally, 24 cases were completed the study. Serum levels of IL-10 and IL-13 were measured on admission time, and 6 months later. Furthermore, chest radiography was performed on admission and 6 months later in the treatment course.ResultsRadiography at the baseline indicated pulmonary infiltration in all patients (n = 24). Fifteen (62.5%) cases had abnormal and 9 (37.5%) cases had normal radiography at the end of 6 months treatment course. IL-10 and IL-13 upregulated during the treatment time course, and their relationship with radiographic changes shifted from negative (r = -0.14 and P = 0.71) on admission to positive (r = 0.80 and P < 0.001) at the end of 6 months treatment course in normal radiography group. IL-10 level at the start of the treatment was 121.90 ± 88.81 in patients with normal and 82.68 ± 41.50 in patients with abnormal radiography (P = 0.31).ConclusionSequential increase in IL-10 and IL-13 during PTB treatment course may have a role in clearing the TB-related radiographic infiltration and preventing scar formation.Copyright: © 2020 Journal of Research in Medical Sciences.

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