• Di Minno Matteo Nicola Dario MND Department of Translational Medical Sciences, Federico II University, Via S. Pansini 5, 80131 Naples, Italy. Electronic address: dario.di, Francesco Forte, Antonella Tufano, Agostino Buonauro, Francesca Wanda Rossi, Amato De Paulis, and Maurizio Galderisi.
• Department of Translational Medical Sciences, Federico II University, Via S. Pansini 5, 80131 Naples, Italy. Electronic address: dario.diminno@hotmail.it.
• Eur. J. Intern. Med. 2020 Mar 1; 73: 16-22.

BackgroundSystemic lupus erythematosus (SLE), is characterized by a systemic involvement including myocardial dysfunction. Being standard echocardiography not able at fully detecting subclinical alterations, speckle tracking echocardiography (STE) has recently emerged as a quantitative ultrasound technique to accurately estimate myocardial function.MethodsWe conducted a systematic review with meta-analysis of studies reporting STE parameters in patients with SLE.ResultsA total of 9 studies were included in the analysis. Left ventricle global longitudinal strain (GLS) was significantly lower in SLE patients than in non-SLE controls (MD: -2.331, 95% CI: -3.083, -1.580, p < 0.001). In addition, we found significant differences between SLE patients and non-SLE controls in left ventricle GLS rate (MD: -0.115, 95% CI: -0.177 to 0.063, p < 0.001), left ventricle circumferential strain(MD: -1.841, 95% CI: -3.160 to 0.521, p = 0.006) and left ventricle radial strain(MD: -11.03, 95% CI: -13.819 to 8.241, p < 0.001). Right ventricle strain was significantly lower in SLE patients than in non-SLE controls (MD: -5.814, 95% CI: -7.347, -4.281, p < 0.001). Meta-regression models showed a lower difference in left ventricle GLS between SLE cases and controls for studies with a higher prevalence of female gender and higher prevalence of hypertension.ConclusionsSLE patients have lower STE parameters than controls, thus suggesting the presence of an impaired myocardial function involving both left and right ventricle.Copyright © 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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