• Linlin Bao, Hong Gao, Wei Deng, Qi Lv, Haisheng Yu, Mingya Liu, Pin Yu, Jiangning Liu, Yajin Qu, Shuran Gong, Kaili Lin, Feifei Qi, Yanfeng Xu, Fengli Li, Chong Xiao, Jing Xue, Zhiqi Song, Zhiguang Xiang, Guanpeng Wang, Shunyi Wang, Xing Liu, Wenjie Zhao, Yunlin Han, Qiang Wei, and Chuan Qin.
• NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
• J. Infect. Dis. 2020 Jul 23; 222 (4): 551-555.

AbstractWe simulated 3 transmission modes, including close-contact, respiratory droplets and aerosol routes, in the laboratory. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be highly transmitted among naive human angiotensin-converting enzyme 2 (hACE2) mice via close contact because 7 of 13 naive hACE2 mice were SARS-CoV-2 antibody seropositive 14 days after being introduced into the same cage with 3 infected-hACE2 mice. For respiratory droplets, SARS-CoV-2 antibodies from 3 of 10 naive hACE2 mice showed seropositivity 14 days after introduction into the same cage with 3 infected-hACE2 mice, separated by grids. In addition, hACE2 mice cannot be experimentally infected via aerosol inoculation until continued up to 25 minutes with high viral concentrations.© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.

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