• Int. J. Clin. Pract. · Apr 2021

    Postprandial triglyceridemia is modulated by insulin resistance but not by grade of obesity in abdominal and morbid obese subjects.

    • Beatriz Moreno-Pérez, Esther Benito, Miguel Civera, Blanca Alabadi, Sergio Martinez-Hervas, Marta Peiro, Herminia González-Navarro, Laura Piqueras, Sanz Maria Jesús MJ Institute of Health Research of the Hospital Clinico Universitario de Valencia (INCLIVA), Valencia, Spain. , Juan F Ascaso, and Jose T Real.
    • Service of Endocrinology and Nutrition, Hospital Clínico Universitario de Valencia, Valencia, Spain.
    • Int. J. Clin. Pract. 2021 Apr 1; 75 (4): e13776.

    BackgroundObesity is associated with high cardiovascular risk. Postprandial lipidaemia has been associated with cardiovascular disease risk. Our aim was to identify whether anthropometric parameters, insulin resistance (IR) and/or fasting plasma triglycerides may determine postprandial changes in lipoprotein concentrations in abdominal and morbid obese subjects.MethodsWe have studied 20 non-diabetic, normolipidaemic subjects with abdominal obesity, 20 morbid obese subjects and 20 healthy individuals, that have similar age and gender. In all of them a standardised oral fat load test (OFLT) with unsaturated fat was performed.ResultsDuring the OFLT, the postprandial triglycerides response was significantly higher in subjects with abdominal obesity compared with morbid obese subjects (4 hours triglycerides pick value and AUC of triglycerides). Both obese groups showed significantly higher postprandial triglycerides response compared with healthy subjects. Dividing the obesity group according to the presence of IR, we found that IR was an important factor related with postprandial lipaemia but not BMI or waist circumference. In addition, postprandial glycaemia and insulinaemia significantly decreased in all studied subjects, being the highest decrease in morbid obese subjects and in subjects with IR. Postprandial triglyceridaemia significantly correlated with IR parameters and not with anthropometric parameters in AO and MO subjects.ConclusionIn subjects with AO and MO, postprandial triglycerides values are higher than healthy individuals and independently predicted by fasting IR parameters. Furthermore, unsaturated fat improved IR state.© 2020 John Wiley & Sons Ltd.

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