• Atsushi Ichikawa, Yoshihisa Matsumura, Hiroshi Ohnishi, Hiromi Kataoka, Katsumi Ogura, Akihito Yokoyama, and Tetsuro Sugiura.
• Department of Laboratory Medicine, Kochi Medical School, Kochi University, Japan.
• Heart Lung. 2016 Jul 1; 45 (4): 359-62.

BackgroundThe purpose of this study was to investigate the association between respiratory function and electrocardiogram (ECG) characteristics in patients with chronic obstructive pulmonary disease (COPD), and to identify the ECG results that indicate possible COPD.MethodsThe association between respiratory function and ECG results was retrospectively analyzed in 45 patients with COPD and 100 patients without COPD (controls).ResultsMultiple logistic regression analysis revealed that QRS amplitude in lead І was a significant predictor of COPD (partial regression coefficient = -4.208, p = 0.002). Receiver operating characteristic curve analysis showed that a QRS amplitude less than 0.54 mV in lead І indicated possible COPD (sensitivity: 71%, specificity: 76%, area under the curve: 0.78 [95% confidence interval: 0.69-0.86], p < 0.001).ConclusionLow voltage in lead І (QRS less than 0.54 mV) is an important criterion in detecting COPD.Copyright © 2016 Elsevier Inc. All rights reserved.

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