• John Rani Toll RT Division of Neuro and Inflammation Science, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University and Depar, Joakim Henricson, Gert E Nilsson, Daniel Wilhelms, and Chris D Anderson.
• Division of Neuro and Inflammation Science, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University and Department of Emergency Medicine, Local Health Care Services in Central Östergötland, Region Östergötland, 58185, Linköping, Sweden.
• J Biophotonics. 2018 Jan 1; 11 (1).

AbstractTo use Bioengineering methodology is used to achieve, at five anatomical sites, a detailed, quantitative assessment of the return of blood content to the blanched area, during the Capillary Refill (CR) test. An observational, non-randomized, experimental study on 23 healthy subjects (14 females) was performed in our climate controlled skin physiology laboratory. Our main outcome measures were based on the chronological assessment and quantification of red blood cell concentration (RBC) after the release of blanching pressure in the CR test, using Tissue Viability Imaging (TiVi), a digital photographic technique based on polarisation spectroscopy. TiVi enabled collection of detailed data on skin RBC concentration during the CR test. The results were shown as curves with skin blood concentration (TiVi-value) on the y-axis and the time on the x-axis. Quantitative CR responses showed site and temperature variability. We also suggest possible objective endpoint values from the capillary refill curve. Detailed data on skin RBC concentration during the CR test is easily obtained and allows objective determination of end points not possible to achieve by naked eye assessment. These findings have the potential to place the utility of the CR test in a clinical setting in a new light. Picture: Regular photograph and TiVi Image showing CR test and corresponding graph for the CR response.© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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