• Antiviral research · Jul 2020

    Antiviral activities of type I interferons to SARS-CoV-2 infection.

    • Emily Mantlo, Natalya Bukreyeva, Junki Maruyama, Slobodan Paessler, and Cheng Huang.
    • Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
    • Antiviral Res. 2020 Jul 1; 179: 104811.

    AbstractThere is an urgent need to identify antivirals to curtail the COVID-19 pandemic. Herein, we report the sensitivity of SARS-CoV-2 to recombinant human interferons α and β (IFNα/β). Treatment with IFN-α or IFN-β at a concentration of 50 international units (IU) per milliliter reduces viral titers by 3.4 log or over 4 log, respectively, in Vero cells. The EC50 of IFN-α and IFN-β treatment is 1.35 IU/ml and 0.76 IU/ml, respectively, in Vero cells. These results suggest that SARS-CoV-2 is more sensitive than many other human pathogenic viruses, including SARS-CoV. Overall, our results demonstrate the potential efficacy of human Type I IFN in suppressing SARS-CoV-2 infection, a finding which could inform future treatment options for COVID-19.Copyright © 2020 Elsevier B.V. All rights reserved.

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