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Antimicrob. Agents Chemother. · Jun 2020
Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025).
- Laurent Softic, Rozenn Brillet, François Berry, Nazim Ahnou, Quentin Nevers, Margot Morin-Dewaele, Sabah Hamadat, Patrice Bruscella, Slim Fourati, Jean-Michel Pawlotsky, and Abdelhakim Ahmed-Belkacem.
- Research Team "Viruses, Hepatology, Cancer," Institut Mondor de Recherche Biomédicale, INSERM U955, Créteil, France.
- Antimicrob. Agents Chemother. 2020 Jun 23; 64 (7).
AbstractCyclophilins play a key role in the life cycle of coronaviruses. Alisporivir (Debio 025) is a nonimmunosuppressive analogue of cyclosporine with potent cyclophilin inhibition properties. Alisporivir reduced SARS-CoV-2 RNA production in a dose-dependent manner in Vero E6 cells, with a 50% effective concentration (EC50) of 0.46 ± 0.04 μM. Alisporivir inhibited a postentry step of the SARS-CoV-2 life cycle. These results justify rapidly conducting a proof-of-concept phase 2 trial with alisporivir in patients with SARS-CoV-2 infection.Copyright © 2020 American Society for Microbiology.
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