• Turkish J Pediatr · Jul 2006

    Case Reports

    Successful bone marrow transplantation in an 8-month-old patient with chronic granulomatous disease.

    • Savaş Kansoy, Necil Kütükçüler, Serap Aksoylar, Güzide Aksu, Mehmet Kantar, and Nazan Cetingül.
    • Department of Pediatric Oncology and Pediatric BMT Center, Ege University Faculty of Medicine, Izmir, Turkey.
    • Turkish J Pediatr. 2006 Jul 1; 48 (3): 253-5.

    AbstractAn eight-month-old boy with chronic granulomatous disease (CGD) received HLA identical sibling bone marrow transplantation (BMT) following busulphan and cyclophosphamide conditioning. No graft-versus-host disease was demonstrated. Five years after transplantation, mixed chimerism was 60% in peripheral blood, and 85% of his neutrophils had normal oxidative burst activity. He is now six years old, in very good health and growing well. In this period, he experienced no severe infectious diseases. To our knowledge, this is the first case of CGD who had BMT in Turkey. His successful outcome illustrates that BMT in a patient with CGD in the first years of life should be considered early if an HLA-matched donor is already available, before development of any recurrent life-threatening infections or irreversible organ damage.

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